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|Title: ||Hyperviscosity syndrome in a dog with IgM secreting lymphoma|
|Authors: ||Wilcox, Elizabeth L.|
|Keywords: ||Dogs -- Diseases -- Case studies|
|Issue Date: ||8-Oct-2003|
|Series/Report no.: ||Senior seminar paper|
Seminar SF610.1 2004 W553
|Abstract: ||On June 13, 2003 a 6 year old intact female beagle, "Molly", presented with the
major complaint of buphthalmia and red eye. She was previously diagnosed and treated
by her veterinarian for glaucoma. She was referred to Cornell for further examination.
After an ophthalmic examination, Molly was diagnosed with hyperviscosity syndrome.
Hyperviscosity syndrome is a rare condition associated with an increase in the
concentration of macroglobulins in the blood. There are various manifestations of
hyperviscosity syndrome with paraproteinaemicus retinopathy (tortuous, distended retinal
veins) being pathognomonic. Other manifestations of hyperviscosity syndrome are
hemorrhaging, especially retinal and gastrointestinal, visual defects, and neurologic
Causes of hyperviscosity syndrome include multiple myeloma, chronic
lymphocytic leukemia, primary (Waldenstrom's) macroglobulinemia, and
lymphosarcoma with monoclonal elaboration of IgM, IgA, and IgG immunoglobulin and
light chain protein classes. After an extensive diagnostic work up it was determined that
Molly had a IgM secreting lymphoma of possible B-cell origin.
Hyperviscosity is treated by reducing serum viscosity. This is best accomplished
by treating the primary disease. Appropriate chemotherapy for Molly's lymphoma
consists of the CHOP protocol which consists of L-asparaginase, prednisone,
doxorubicin, cyclophosphamide, and vincristine. This would have been the most optimal
treatment for this dog. However, the owner elected to forgo expensive chemotherapy and
treat Molly with a pallative course of prednisone.|
|Description: ||Senior seminar (D.V.M.) -- Cornell University, 2004.
Includes bibliographical references (leaf 8).|
|Appears in Collections:||Senior Seminars|
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