Along a 450 km transect across central Syria seismic reflection data, borehole information, potential field data and surface geologic mapping have been combined to examine the crustal structure of the northern Arabian platform beneath Syria. The transect is surrounded by the major plate boundaries of the Middle East, including the Dead Sea transform fault system along the Levantine margin to the west, the Bitlis suture and East Anatolian fault to the north, and the Zagros collisional belt to the northeast and east. Three main tectonic provinces of the northern Arabian platform in Syria are crossed by this transect from south to north: the Rutbah uplift, the Palmyra fold-thrust belt, and the Aleppo plateau. The Rutbah uplift in southern Syria is a broad, domal basement-cored structure with a thick Phanerozoic (mostly Paleozoic) cover of 6-7 km. Isopachs based on well and seismic reflection data indicate that this region was an early Paleozoic depocenter. The Palmyra fold-thrust belt, the northeastern arm of the Syrian Arc, is a northeast- southwest trending intracontinental mountain belt that acts as a mobile tectonic zone between the relatively stable Rutbah uplift to the south and the less stable Aleppo plateau to the north. Short wavelength en echelon folds characterized by relatively steep, faulted southeast flanks dominate in the southwest, most strongly deformed segment of the belt, while a complex system of deeply rooted faults and broad folds characterize the northeast region, described in this study. The Aleppo plateau lies immediately north of the Palmyride belt, with a combined Paleozoic and Mesozoic sedimentary section that averages 4-5 km in thickness. Although this region appears relatively undeformed on seismic reflection data when compared to Palmyride deformation, a system of near vertical, probable strike-slip faults crosscut the region in a dominantly northeasterly direction. Gravity and magnetic modeling constrains the deep crustal structure along the transect. The crustal thickness is estimated to be approximately 38 km. Interpretation of the gravity data indicates two different crustal blocks beneath the Rutbah uplift and the Aleppo plateau, and the presence of a crustal-penetrating, high-density body beneath the northeast Palmyrides. The two distinct crustal blocks suggest that they were accreted possibly along a suture zone and/or a major strike-slip fault zone located approximately in the present-day position of the Palmyrides. The age of the accretion is estimated to be Proterozoic or early Cambrian, based on the observation of a pervasive reflection (interpreted as the Middle Cambrian Burj limestone) in the Rutbah uplift and in the Aleppo plateau and by analogy with the well-mapped Proterozoic sutures of the Arabian shield to the south.