Data from: Structural Origins of Cartilage Shear Mechanics
| dc.contributor.author | Wyse Jackson, Thomas | |
| dc.contributor.author | Michel, Jonathan | |
| dc.contributor.author | Lwin, Pancy | |
| dc.contributor.author | Fortier, Lisa A. | |
| dc.contributor.author | Das, Moumita | |
| dc.contributor.author | Bonassar, Lawrence J. | |
| dc.contributor.author | Cohen, Itai | |
| dc.date.accessioned | 2022-02-23T16:38:45Z | |
| dc.date.available | 2022-02-23T16:38:45Z | |
| dc.date.issued | 2022-02-22 | |
| dc.description.abstract | These files contain data supporting all results reported in Wyse Jackson et. al. . In Wyse Jackson et al., we found: Articular cartilage is a remarkable material able to sustain millions of loading cycles over decades of use outperforming any synthetic substitute. Crucially, how extracellular matrix constituents alter mechanical performance, particularly in shear, remains poorly understood. Here, we present experiments and theory in support of a rigidity percolation framework that quantitatively describes the structural origins of cartilage’s shear properties and how they arise from the mechanical interdependence of the collagen and aggrecan networks making up its extracellular matrix. This framework explains that near the cartilage surface, where the collagen network is sparse and close to the rigidity threshold, slight changes in either collagen or aggrecan concentrations, common in early stages of cartilage disease, create a marked weakening in modulus that can lead to tissue collapse. More broadly, this framework provides a map for understanding how changes in composition throughout the tissue alter its shear properties and ultimate in vivo function. | en_US |
| dc.description.sponsorship | This work was supported by the National Science Foundation grants DMR-1807602, DMR-1808026, CBET-1604712, CMMI 1927197, and BMMB-1536463. This work was also supported by the NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases, Contract: 5R01AR071394-04. Last, this work made use of the Cornell Center for Materials Research Facilities supported by the National Science Foundation under Award Number DMR-1719875. | en_US |
| dc.identifier.doi | https://doi.org/10.7298/fz4d-cy87 | |
| dc.identifier.uri | https://hdl.handle.net/1813/111003 | |
| dc.language.iso | en_US | en_US |
| dc.relation.isreferencedby | Thomas Wyse Jackson, Michel Jonathan, Lwin Pancy, Fortier Lisa A., Das Moumita, Bonassar Lawrence J., and Cohen Itai. “Structural Origins of Cartilage Shear Mechanics.” Science Advances 8(6): eabk2805. https://doi.org/10.1126/sciadv.abk2805. | |
| dc.relation.isreferencedbyuri | https://doi.org/10.1126/sciadv.abk2805 | |
| dc.rights | Attribution 4.0 International | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject | FTIR | en_US |
| dc.subject | confocal elastography | en_US |
| dc.subject | histology | en_US |
| dc.subject | local structure | en_US |
| dc.subject | rigidity percolation | en_US |
| dc.title | Data from: Structural Origins of Cartilage Shear Mechanics | en_US |
| dc.type | dataset | en_US |
| schema.accessibilityHazard | none | en_US |